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The effects of cannabis extracts Tetranabinex and Nabidiolex on human cyclo-oxygenase activity. International Cannabinoid Research Society; June 2005; Clearwater, FL. Randomized controlled trial of cannabis based medicine in central neuropathic pain due to multiple sclerosis. Richardson JD, Aanonsen L, Hargreaves KM. Antihyperalgesic effects of spinal cannabinoids.

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Interestingly, most hemp farmers consider CBD oil a byproduct of industrial hemp that is initially grown for other purposes. The effects of cannabis extracts Tetranabinex and Nabidiolex on human cytochrome P450-mediated metabolism. International Cannabinoid Research Association; June ; Clearwater, FL.

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana. The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Potency trends of delta9-THC and other cannabinoids in confiscated marijuana from 1980–1997. Are cannabinoids an effective and safe option in the management of pain?

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No long-term mood disorders have been associated with Sativex administration. Debate continues as to the existence of a clinically significant cannabis withdrawal syndrome with proponents , and questioners . While symptoms recurred after 7–10 days of abstinence from Sativex, prior levels of symptom control were readily re-established upon re-titration of the agent .

Burstein S, Levin E, Varanelli C. Prostaglandins and cannabis. Inhibition of biosynthesis by the naturally occurring cannabinoids. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine in the treatment of pain caused by rheumatoid arthritis. Short-term effects of cannabinoids in patients with HIV-1 infection.

On additional study, at 314 ng/ml cannabinoid concentration, Sativex and components produced no significant induction on human CYP450 . Thus, Sativex should be safe to use in conjunction with other drugs metabolized via this pathway. Slight improvements were observed in Hospital Anxiety and Depression Scales depression and anxiety scores were noted with Sativex in MS patients with central neuropathic pain , although not quite statistically significant.

Cannabinoids may offer significant “side benefits” beyond analgesia. No effects of THC extract, CBD extract or CBD oil Sativex were observed in a study of effects on the hepatic cytochrome P450 complex .

No dose tolerance to the therapeutic effects of Sativex has been observed in clinical trials in over 1500 patient-years of administration. The degree to which a drug is reinforcing is determined partly by the by the rate of its delivery to the brain .